Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700356 | 0.88 | AURKA (0.40) | ALDH1A1L3MBTL1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL10700212 | 0.86 | ALDH1A1 (0.37) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10694215 | 0.85 | ELANE (0.46) | ELANEALDH1A1TDP1KDM4EPGR | |
| SCHEMBL10700914 | 0.84 | HPGD (0.38) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10695135 | 0.83 | CREBBP (0.41) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL10696420 | 0.82 | ELANE (0.43) | ELANEALDH1A1LMNACYP3A4CYP2C9 | |
| SCHEMBL10696091 | 0.79 | TDP1 (0.54) | ELANEALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10697407 | 0.73 | AURKA (0.40) | PGR | |
| SCHEMBL10696040 | 0.73 | AURKA (0.49) | LMNAL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL10700189 | 0.73 | ALDH1A1 (0.37) | ALDH1A1LMNAKDM4EPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |