Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696420 | 0.89 | ELANE (0.43) | ELANETDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL10696091 | 0.87 | TDP1 (0.54) | ELANETDP1ALDH1A1MAPTADAMTS5 | |
| SCHEMBL10696613 | 0.85 | AURKA (0.40) | TDP1ALDH1A1HSD17B10KDM4EPDE4A | |
| SCHEMBL10696048 | 0.85 | ELANE (0.44) | ELANETDP1ALDH1A1KDM4EPGR | |
| SCHEMBL10696042 | 0.84 | ALDH1A1 (0.39) | TDP1ALDH1A1HSD17B10KDM4EPDE4A | |
| SCHEMBL10698603 | 0.83 | ALDH1A1 (0.39) | TDP1ALDH1A1HSD17B10KDM4EPDE4A | |
| SCHEMBL10696397 | 0.82 | ALDH1A1 (0.40) | TDP1ALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL10698037 | 0.82 | ALDH1A1 (0.38) | TDP1ALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL10693698 | 0.81 | KDM4E (0.40) | ALDH1A1HSD17B10KDM4E | |
| SCHEMBL10695498 | 0.80 | ALDH1A1 (0.43) | TDP1ALDH1A1HSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |