Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10703903 | 0.94 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AKMT2ANPC1NFKB1 | |
| SCHEMBL10714503 | 0.90 | ALDH1A1 (0.53) | SMN1; SMN2RAB9AKMT2ANPC1NFKB1 | |
| SCHEMBL10696545 | 0.84 | LMNA (0.38) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL2490357 | 0.83 | MAPT (0.56) | RAB9AKMT2ANPC1ALDH1A1PKM | |
| SCHEMBL10699652 | 0.83 | NPC1 (0.49) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL10700893 | 0.83 | SETD7 (0.41) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL10698960 | 0.82 | MAPT (0.41) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL10701527 | 0.81 | MAPT (0.49) | SMN1; SMN2KMT2ANPC1ALDH1A1MEN1 | |
| SCHEMBL10699942 | 0.81 | MAPT (0.51) | SMN1; SMN2RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL10696534 | 0.81 | MAPT (0.42) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |