Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697809 | 0.86 | CNR1 (0.39) | BRD4CNR1GPR55MEN1KMT2A | |
| SCHEMBL10695178 | 0.85 | KDM4E (0.38) | CREBBPBRD4MEN1KMT2APDE4A | |
| SCHEMBL10700743 | 0.85 | MEN1 (0.33) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL10698820 | 0.79 | KDM4E (0.42) | CREBBPBRD4MEN1KMT2ARAB9A | |
| SCHEMBL10696706 | 0.77 | ALDH1A1 (0.41) | CREBBPBRD4RAB9APDE4APDE4B | |
| SCHEMBL10694978 | 0.76 | MEN1 (0.36) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL10691737 | 0.76 | MEN1 (0.36) | CREBBPBRD4MEN1KMT2ARAB9A | |
| SCHEMBL10697525 | 0.74 | MEN1 (0.36) | MEN1KMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL10698674 | 0.73 | KDM4E (0.34) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL10697223 | 0.73 | MEN1 (0.38) | MEN1KMT2ARAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |