Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | PDE4A | P27815 | 2/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.60 |
| ▸ | PDE1A | P54750 | 1/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946890 | 0.96 | POLB (0.67) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL3186736 | 0.94 | CNOT7 (0.61) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL3112709 | 0.92 | POLB (0.68) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL7604892 | 0.89 | KMT2A (0.61) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL1944712 | 0.89 | POLB (0.70) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL1945875 | 0.88 | KMT2A (0.69) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL556098 | 0.88 | PDE1A (0.70) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL3106268 | 0.88 | LMNA (0.58) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 | |
| SCHEMBL10697104 | 0.86 | PDE4A (0.79) | ALDH1A1CNOT7SMN1; SMN2ADORA2BTSHR | |
| SCHEMBL27369794 | 0.85 | KMT2A (0.63) | ALDH1A1CNOT7POLBHIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-04-22 | — | — | US | disclosed |
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-04-22 | — | — | US | disclosed |
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-04-22 | — | — | US | disclosed |
| EP-1912993-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SmithKline Beecham Corporation (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017265-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | GPR84, GPR88, HCAR1 | ALDH1A1 840/4885CNOT7 3355/4885POLB 3234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.