Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696205 | 0.95 | CA12 (0.51) | CA12CA9NPC1RAB9ATRIM24 | |
| SCHEMBL10699129 | 0.87 | NPC1 (0.48) | CA12CA9NPC1RAB9AL3MBTL1 | |
| SCHEMBL10699776 | 0.83 | CA12 (0.44) | CA12CA9NPC1RAB9AL3MBTL1 | |
| SCHEMBL10701670 | 0.82 | NPC1 (0.48) | CA12CA9NPC1RAB9AL3MBTL1 | |
| SCHEMBL10698199 | 0.81 | CA12 (0.46) | CA12CA9NPC1RAB9AL3MBTL1 | |
| SCHEMBL10695099 | 0.80 | MEN1 (0.48) | CA12CA9TRIM24DHFRMEN1 | |
| SCHEMBL10694299 | 0.78 | CYP11B1 (0.54) | TRIM24CYP19A1 | |
| SCHEMBL10691731 | 0.76 | TRIM24 (0.44) | CA12CA9NPC1RAB9ATRIM24 | |
| SCHEMBL10696700 | 0.76 | CA12 (0.50) | CA12CA9NPC1RAB9AL3MBTL1 | |
| SCHEMBL10695565 | 0.76 | CBFB (0.55) | NPC1RAB9AL3MBTL1KMT2AMETAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |