Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 7/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 7/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695099 | 0.86 | MEN1 (0.48) | TRIM24MEN1KMT2ACA1CA2 | |
| SCHEMBL10700170 | 0.86 | BMPR1B (0.38) | TRIM24MEN1KMT2ACA1CA2 | |
| SCHEMBL10701774 | 0.86 | TRIM24 (0.43) | TRIM24MEN1KMT2ACHEK2CDC25A | |
| SCHEMBL10702791 | 0.81 | BMPR1B (0.42) | TRIM24MEN1KMT2ACA1CA2 | |
| SCHEMBL10694299 | 0.80 | CYP11B1 (0.54) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL10700889 | 0.79 | BMPR1B (0.43) | MEN1KMT2ACA1CA2CA12 | |
| SCHEMBL10697210 | 0.76 | CA12 (0.51) | TRIM24MEN1KMT2ACA12CA9 | |
| SCHEMBL10697238 | 0.75 | CYP11B1 (0.54) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL10694972 | 0.75 | MEN1 (0.40) | MEN1KMT2ACA1CA2CA12 | |
| SCHEMBL10697084 | 0.75 | MEN1 (0.40) | MEN1KMT2ACA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |