Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 6/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CDC25C | P30307 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691731 | 0.86 | TRIM24 (0.44) | MEN1KMT2ATRIM24ACVRL1ACVR1 | |
| SCHEMBL10694299 | 0.86 | CYP11B1 (0.54) | TRIM24ATMACVRL1ACVR1BMPR1B | |
| SCHEMBL10698124 | 0.86 | MEN1 (0.44) | MEN1KMT2ATRIM24ATMACVRL1 | |
| SCHEMBL10701774 | 0.84 | TRIM24 (0.43) | MEN1KMT2ATRIM24CDC25ACDC25B | |
| SCHEMBL10697238 | 0.81 | CYP11B1 (0.54) | TRIM24ATMACVRL1ACVR1BMPR1B | |
| SCHEMBL10697210 | 0.80 | CA12 (0.51) | MEN1KMT2ATRIM24CA12CA9 | |
| SCHEMBL10696205 | 0.75 | CA12 (0.51) | MEN1KMT2ATRIM24CA12CA9 | |
| SCHEMBL10697017 | 0.74 | ALDH1A1 (0.49) | TRIM24PDE3BPDE3AKIT | |
| SCHEMBL10695172 | 0.74 | MEN1 (0.47) | MEN1KMT2AATMPDE3BPDE3A | |
| SCHEMBL10695550 | 0.74 | MEN1 (0.47) | MEN1KMT2AATMPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |