Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705366 | 0.82 | TP53 (0.42) | AMY1AAURKAKDRPDE4APDE4B | |
| SCHEMBL10700489 | 0.79 | NPC1 (0.49) | AURKAKDRNPC1RAB9APDE4A | |
| SCHEMBL9703298 | 0.78 | PDE5A (0.38) | AMY1AAURKAKDRNPC1RAB9A | |
| SCHEMBL9703362 | 0.77 | PDE5A (0.37) | AMY1AAURKAKDRPDE4APDE4B | |
| SCHEMBL9383861 | 0.77 | CDK4 (0.41) | AMY1APDE3BPDE3ANPBWR1 | |
| SCHEMBL10373866 | 0.77 | PDE4A (0.50) | AMY1AAURKANPC1RAB9AATM | |
| SCHEMBL10697003 | 0.77 | AMY1A (0.45) | AMY1AAURKAKDRNPC1RAB9A | |
| SCHEMBL9703307 | 0.77 | PDE4A (0.34) | AMY1AAURKAKDRNPC1RAB9A | |
| SCHEMBL9385702 | 0.76 | PDE4A (0.59) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL9704386 | 0.76 | PDE2A (0.39) | AMY1AAURKAKDRPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |