Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705366 | 0.86 | TP53 (0.42) | PDE5APDE3BPDE3AAMY1AAURKA | |
| SCHEMBL10558256 | 0.85 | AMY1A (0.39) | PDE5APDE3BPDE3AAMY1APDE2A | |
| SCHEMBL9383861 | 0.85 | CDK4 (0.41) | PDE5APDE3BPDE3AAMY1A | |
| SCHEMBL9703428 | 0.85 | PDE3B (0.41) | PDE5APDE3BPDE3AAMY1AAURKA | |
| SCHEMBL9703298 | 0.84 | PDE5A (0.38) | PDE5APDE3BPDE3AAMY1AAURKA | |
| SCHEMBL9704386 | 0.81 | PDE2A (0.39) | PDE5APDE3BPDE3AAMY1AAURKA | |
| SCHEMBL9703649 | 0.79 | AMY1A (0.43) | PDE5APDE3BPDE3AAMY1APDE2A | |
| SCHEMBL10373752 | 0.78 | PDE3B (0.48) | PDE5APDE3BPDE3AAMY1AAURKA | |
| SCHEMBL9703453 | 0.77 | AMY1A (0.37) | PDE5APDE3BPDE3AAMY1AAURKA | |
| SCHEMBL10700489 | 0.77 | NPC1 (0.49) | PDE3BPDE3AAURKAKDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |