Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696376 | 0.94 | POLB (0.43) | MAPTPOLBKMT2AMEN1LMNA | |
| SCHEMBL10701527 | 0.86 | MAPT (0.49) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL10698400 | 0.86 | MAPT (0.47) | MAPTPOLBKMT2AMEN1LMNA | |
| SCHEMBL10698960 | 0.85 | MAPT (0.41) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL10532531 | 0.85 | MAPT (0.40) | MAPTPOLBKMT2AMEN1LMNA | |
| SCHEMBL10699998 | 0.83 | MAPT (0.49) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL10697943 | 0.82 | MAPT (0.41) | MAPTPOLBKMT2AMEN1LMNA | |
| SCHEMBL10530680 | 0.81 | POLB (0.41) | MAPTPOLBKMT2AMEN1LMNA | |
| SCHEMBL10696545 | 0.80 | LMNA (0.38) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL10699997 | 0.79 | MAPT (0.51) | MAPTPOLBKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |