Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CCL2 | P13500 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700950 | 0.90 | MEN1 (0.36) | MEN1KMT2ASMN1; SMN2TDP1BRD4 | |
| SCHEMBL10699882 | 0.89 | KDM4E (0.35) | LMNASMN1; SMN2RECQLTDP1BRD4 | |
| SCHEMBL10698690 | 0.89 | MEN1 (0.33) | MEN1KMT2ALMNARAB9AMAPT | |
| SCHEMBL10700985 | 0.87 | KMT2A (0.36) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL10698630 | 0.85 | KMT2A (0.37) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL10694978 | 0.82 | MEN1 (0.36) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL10698445 | 0.82 | MEN1 (0.36) | MEN1KMT2ASMN1; SMN2TDP1BRD4 | |
| SCHEMBL10698552 | 0.79 | PDE6D (0.36) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL10699480 | 0.79 | KDM4E (0.34) | TDP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10700358 | 0.74 | TNKS2 (0.43) | MEN1KMT2ALMNASMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |