Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 8/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385702 | 0.88 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10700489 | 0.84 | NPC1 (0.49) | NPBWR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10559564 | 0.82 | NPBWR1 (0.51) | NPBWR1DGAT1PDE4APDE4BPDE4C | |
| SCHEMBL9384373 | 0.74 | AURKA (0.39) | DGAT1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9378614 | 0.74 | KDM4E (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL807772 | 0.74 | PARP10 (0.54) | — | |
| SCHEMBL10373612 | 0.73 | PDE4A (0.67) | NPBWR1DGAT1PDE4APDE4BPDE4C | |
| SCHEMBL9703360 | 0.73 | PDE4A (0.49) | NPBWR1DGAT1PDE4APDE4BPDE4C | |
| SCHEMBL9705366 | 0.73 | TP53 (0.42) | NPBWR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10697321 | 0.71 | AMY1A (0.45) | NPBWR1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |