Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699537 | 0.85 | HSD11B1 (0.53) | LMNASMN1; SMN2HSD11B1HTR2AALDH1A1 | |
| SCHEMBL10698595 | 0.81 | HSD11B1 (0.46) | LMNAHSD11B1NPC1HTR2AALDH1A1 | |
| SCHEMBL7300582 | 0.79 | LMNA (0.51) | LMNAHTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9374409 | 0.77 | KMT2A (0.52) | LMNASMN1; SMN2HTR2AALDH1A1CYP2D6 | |
| SCHEMBL6009365 | 0.76 | HTR2A (0.46) | LMNASMN1; SMN2HTR2AKDM4ECYP1A2 | |
| SCHEMBL5756938 | 0.75 | HTR2A (0.52) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5756941 | 0.73 | GAA (0.46) | LMNASMN1; SMN2HSD11B1ALDH1A1CYP1A2 | |
| SCHEMBL3838687 | 0.71 | HTR2A (0.61) | LMNASMN1; SMN2HTR2AKDM4ECYP1A2 | |
| SCHEMBL3838690 | 0.71 | HTR2A (0.61) | LMNASMN1; SMN2HTR2AKDM4ECYP1A2 | |
| SCHEMBL3838692 | 0.71 | HTR2A (0.61) | LMNASMN1; SMN2HTR2AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294183-A1 | Use of ethylamine derivatives as antihypertensive agents | AJINOMOTO CO., INC. (JP) | 1988-12-07 | — | — | EP | disclosed |