Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11551008 | 0.84 | CYP1A2 (0.53) | MPOLTB4RAOC3CYP1A2CYP3A4 | |
| SCHEMBL1590088 | 0.82 | GRM4 (0.47) | MPOLTB4RAOC3 | |
| SCHEMBL30811836 | 0.82 | NUDT1 (0.50) | MPOLTB4R | |
| SCHEMBL28507161 | 0.81 | NUDT1 (0.49) | MPOLTB4R | |
| SCHEMBL15400226 | 0.81 | CYP2D6 (0.47) | CYP2D6 | |
| Methyl Alcohol SCHEMBL29176244 | 0.80 | NUDT1 (0.47) | MPOLTB4R | |
| SCHEMBL29558689 | 0.78 | ALDH1A1 (0.54) | CYP2D6 | |
| SCHEMBL30536351 | 0.78 | DHFR (0.46) | — | |
| SCHEMBL27457079 | 0.78 | DHFR (0.46) | — | |
| SCHEMBL2872507 | 0.78 | ADORA2A (0.56) | MPOLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258117-A1 | Process for the preparation of 2,4-diamino-5-benzyl pyrimidines | SANOFI PHARMA SA (CH) | 1988-03-02 | — | — | EP | claimed |
| EP-0061397-B1 | SOLUBLE AND N2 SUBSTITUTED DERIVATIVES OF 2,4-DIAMINO-5-BENZYL-PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | S.A. PANMEDICA Société dite: (FR) | 1986-01-15 | — | — | EP | claimed |
| EP-0061397-A1 | Soluble and N2 substituted derivatives of 2,4-diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them | S.A. PANMEDICA Société dite: (FR) | 1982-09-29 | — | — | EP | claimed |
| EP-0258117-A1 | Process for the preparation of 2,4-diamino-5-benzyl pyrimidines | SANOFI PHARMA SA (CH) | 1988-03-02 | — | — | EP | disclosed |
| EP-0258117-A1 | Process for the preparation of 2,4-diamino-5-benzyl pyrimidines | SANOFI PHARMA SA (CH) | 1988-03-02 | — | — | EP | disclosed |
| EP-0061397-B1 | SOLUBLE AND N2 SUBSTITUTED DERIVATIVES OF 2,4-DIAMINO-5-BENZYL-PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | S.A. PANMEDICA Société dite: (FR) | 1986-01-15 | — | — | EP | disclosed |
| EP-0061397-B1 | SOLUBLE AND N2 SUBSTITUTED DERIVATIVES OF 2,4-DIAMINO-5-BENZYL-PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | S.A. PANMEDICA Société dite: (FR) | 1986-01-15 | — | — | EP | disclosed |
| EP-0061397-A1 | Soluble and N2 substituted derivatives of 2,4-diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them | S.A. PANMEDICA Société dite: (FR) | 1982-09-29 | — | — | EP | disclosed |
| EP-0061397-A1 | Soluble and N2 substituted derivatives of 2,4-diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them | S.A. PANMEDICA Société dite: (FR) | 1982-09-29 | — | — | EP | disclosed |
| EP-0061397-A1 | Soluble and N2 substituted derivatives of 2,4-diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them | S.A. PANMEDICA Société dite: (FR) | 1982-09-29 | — | — | EP | disclosed |