Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13021074 | 0.84 | POLB (0.41) | GAAKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL2900606 | 0.82 | ALDH1A1 (0.44) | L3MBTL1KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5353299 | 0.80 | LMNA (0.45) | GAAL3MBTL1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20985696 | 0.78 | ALDH1A1 (0.36) | L3MBTL1KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19805759 | 0.76 | ADORA2A (0.50) | L3MBTL1KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29975953 | 0.76 | ADORA2A (0.50) | L3MBTL1KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL77207 | 0.76 | HSP90AA1 (0.55) | GAAL3MBTL1KDM4EMAPTALDH1A1 | |
| SCHEMBL13012210 | 0.76 | GAA (0.50) | GAAL3MBTL1KDM4EMAPTALDH1A1 | |
| SCHEMBL254039 | 0.76 | POLB (0.44) | GAAKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8561459 | 0.75 | PTGES (0.43) | GAAL3MBTL1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285978-A2 | Substituted 1-(2-oxyaminosulfonyl-phenylsulfonyl)-3-(4-trifluoromethyl-pyrimidin-2-yl)-(thio)-ureas | BAYER AG (DE) | 1988-10-12 | — | — | EP | disclosed |