Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CCR1 | P32246 | 3/20 | 0.40 |
| ▸ | CCR5 | P51681 | 3/20 | 0.40 |
| ▸ | CCR8 | P51685 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1071469 | 0.82 | SMN1; SMN2 (0.43) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL28517555 | 0.79 | KDM4E (0.54) | LMNACCR1CCR5CCR8KDM4E | |
| Hydrochloric Acid SCHEMBL1072267 | 0.78 | CCR1 (0.40) | LMNACCR1CCR5CCR8KDM4E | |
| Hydrochloric Acid SCHEMBL1071824 | 0.78 | MAPT (0.40) | LMNACCR1CCR5CCR8KDM4E | |
| Hydrochloric Acid SCHEMBL819577 | 0.77 | KDM4E (0.41) | LMNACCR1CCR5CCR8KDM4E | |
| Hydrochloric Acid SCHEMBL5009057 | 0.74 | P2RX7 (0.40) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL27587384 | 0.72 | LMNA (0.39) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL7546290 | 0.70 | MAPK1 (0.37) | LMNACCR1CCR5CCR8KDM4E | |
| SCHEMBL6131342 | 0.69 | CCR1 (0.39) | LMNACCR1CCR5CCR8KDM4E | |
| Hydrochloric Acid SCHEMBL1069659 | 0.68 | CCR1 (0.40) | LMNACCR1CCR5CCR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618912-B2 | Preparation of supported catalyst systems | BASELL POLYOLEFINE GMBH (DE) | 2009-11-17 | — | — | US | claimed |
| US-20060166813-A1 | Preparation of supported catalyst systems | BASELL POLYOLEFINE GMBH (DE) | 2006-07-27 | — | — | US | claimed |
| EP-1824888-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2017-01-18 | — | — | EP | disclosed |
| EP-1740626-B1 | CATALYST SYSTEM FOR OLEFIN POLYMERIZATION, ITS PRODUCTION AND USE | BASELL POLYOLEFINE GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| US-7973114-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2011-07-05 | — | — | US | disclosed |
| EP-1861409-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |
| US-7834107-B2 | Preparation of polyolefins having high molecular weights in the presence of an organic transition metal compound in a gas-phase fluidized-bed reactor | BASELL POLYOLEFINE GMBH (DE) | 2010-11-16 | — | — | US | disclosed |
| US-7834112-B2 | Method of polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2010-11-16 | — | — | US | disclosed |
| US-7795167-B2 | Cyclopentadienyl complexes of group 6 substituted by silyl halides | BASELL POLYOLEFINE GMBH (DE) | 2010-09-14 | — | — | US | disclosed |
| US-7776980-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| EP-1572359-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2010-04-28 | — | — | EP | disclosed |
| US-20040249095-A1 | Method of polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-12-09 | — | — | US | disclosed |
| US-20040242880-A1 | Monocyclopentadienyl complexes comprising a condensed heterocycle | BASELL POLYOLEFINE GMBH (DE) | 2004-12-02 | — | — | US | disclosed |
| US-6787498-B2 | AS CATALYSTS FOR POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2004-09-07 | — | — | US | disclosed |
| US-6699948-B2 | AS CATALYSTS FOR POLYMERIZATION OF OLEFINS | BASF AKTIENGESELLSCHAFT (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20040033890-A1 | Catalyst system for carrying out olefin polymerization comprising a calcined hydro-talcite serving as a supporting material | LYONDELL CHEMICAL TECHNOLOGY, L.P. | 2004-02-19 | — | — | US | disclosed |
| US-20030176275-A1 | Catalytic solid supported on calcined hydrotalcite for olefinic polymerisation | BASELL POLYOLEFINE GMBH (DE) | 2003-09-18 | — | — | US | disclosed |
| US-20030036662-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | MIHAN SHAHRAM (DE) | 2003-02-20 | — | — | US | disclosed |
| US-20030036658-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | MIHAN SHAHRAM (DE) | 2003-02-20 | — | — | US | disclosed |
| US-6437161-B1 | OLEFIN POLYMERIZATION CATALYSTS; SUBSTITUENT ON THE CYCLOPENTADIENYL RING CARRIES A DONOR FUNCTION WHICH IS BONDED RIGIDLY, NOT EXCLUSIVELY VIA SP3-HYBRIDIZED CARBON OR SILICON ATOMS, | BASF AKTIENGESELLSCHAFT (DE) | 2002-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242880-A1 | Monocyclopentadienyl complexes comprising a condensed heterocycle | MCM4, MCM3, CCNC | CHRM1 2515/4885LMNA 3277/4885CCR1 1453/4885 |
| US-20030036662-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | SKIC3, ORC3, MCM3 | CHRM1 1028/4885LMNA 3742/4885CCR1 180/4885 |
| US-20030036658-A1 | Monocyclopentadienyl complexes of chromium, molybdenum or tungsten | SKIC3, ORC3, MCM3 | CHRM1 1028/4885LMNA 3742/4885CCR1 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.