Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.75 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.75 |
| ▸ | DRD3 | P35462 | 1/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025012 | 1.00 | HIF1A (0.75) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL5024973 | 0.93 | HIF1A (0.89) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL14956630 | 0.93 | HIF1A (0.89) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL13696625 | 0.87 | CYP3A4 (0.57) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| SCHEMBL18645038 | 0.86 | HIF1A (0.73) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Melphalan SCHEMBL5872 | 0.86 | HIF1A (1.00) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Sarcolysin SCHEMBL414671 | 0.86 | HIF1A (1.00) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Melphalan SCHEMBL5325132 | 0.86 | HIF1A (1.00) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| (R)-Melphalan SCHEMBL5873 | 0.86 | HIF1A (1.00) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 | |
| Melphalan SCHEMBL563239 | 0.86 | HIF1A (1.00) | HIF1ACYP3A4ALOX15PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575385-B2 | Process of making optically pure melphalan | NAVINTA LLC (US) | 2013-11-05 | — | — | US | claimed |
| EP-2268827-B1 | PROCESS OF MAKING OPTICALLY PURE MELPHALAN | NAVINTA LLC (US) | 2013-10-09 | — | — | EP | claimed |
| EP-2268827-A1 | PROCESS OF MAKING OPTICALLY PURE MELPHALAN | Navinta, llc. (US) | 2011-01-05 | — | — | EP | claimed |
| WO-2009117164-A1 | PROCESS OF MAKING OPTICALLY PURE MELPHALAN | NAVINTA LLC (US) | 2009-09-24 | — | — | WO | claimed |
| US-20090240074-A1 | Process Of Making Optically Pure Melphalan | PROVIDENT BANK | 2009-09-24 | — | — | US | claimed |
| US-10682326-B1 | Stable melphalan liquid injectable formulations | SHILPA MEDICARE LIMITED | 2020-06-16 | — | — | US | disclosed |
| EP-2970102-B1 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF MELPHALAN AND THE HYDROCHLORIDE SALT | BIOPHORE INDIA PHARMACEUTICALS PVT LTD (IN) | 2019-05-08 | — | — | EP | disclosed |
| US-20180237377-A1 | Process for the Synthesis of Melphalan and the Hydrochloride Salt | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2018-08-23 | — | — | US | disclosed |
| US-9963422-B2 | Process for the synthesis of melphalan and the hydrochloride salt | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2018-05-08 | — | — | US | disclosed |
| US-20160016889-A1 | An Improved Process for the Synthesis of Melphalan and the Hydrochloride Salt | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2016-01-21 | — | — | US | disclosed |
| EP-2970102-A2 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF MELPHALAN AND THE HYDROCHLORIDE SALT | Biophore India Pharmaceuticals Pvt. Ltd. (IN) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014141294-A2 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF MELPHALAN AND THE HYDROCHLORIDE SALT | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2014-09-18 | — | — | WO | disclosed |
| EP-2599484-A1 | INJECTABLE PHARMACEUTICAL FORMULATION OF MELPHALAN | Eriochem, S.A. (AR) | 2013-06-05 | — | — | EP | disclosed |
| US-20130131174-A1 | INJECTABLE PHARMACEUTICAL FORMULATION OF MELPHALAN | ERIOCHEM (AR) | 2013-05-23 | — | — | US | disclosed |
| EP-2268827-A1 | PROCESS OF MAKING OPTICALLY PURE MELPHALAN | Navinta, llc. (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2268827-A1 | PROCESS OF MAKING OPTICALLY PURE MELPHALAN | Navinta, llc. (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117164-A1 | PROCESS OF MAKING OPTICALLY PURE MELPHALAN | NAVINTA LLC (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117164-A1 | PROCESS OF MAKING OPTICALLY PURE MELPHALAN | NAVINTA LLC (US) | 2009-09-24 | — | — | WO | disclosed |
| US-20090240074-A1 | Process Of Making Optically Pure Melphalan | PROVIDENT BANK | 2009-09-24 | — | — | US | disclosed |
| US-20090240074-A1 | Process Of Making Optically Pure Melphalan | PROVIDENT BANK | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090240074-A1 | Process Of Making Optically Pure Melphalan | TYR, PAH, TET2 | HIF1A 261/4885CYP3A4 121/4885ALOX15 2166/4885 |
| US-20160016889-A1 | An Improved Process for the Synthesis of Melphalan and the Hydrochloride Salt | MCL1, DCPS, MEN1 | HIF1A 1593/4885CYP3A4 2944/4885ALOX15 4531/4885 |
| US-10682326-B1 | Stable melphalan liquid injectable formulations | IL2, MGMT, MCL1 | HIF1A 1917/4885CYP3A4 4275/4885ALOX15 1060/4885 |
| US-20180237377-A1 | Process for the Synthesis of Melphalan and the Hydrochloride Salt | MCL1, PTMA, DCPS | HIF1A 1191/4885CYP3A4 2499/4885ALOX15 4472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.