Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 7/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 7/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699937 | 0.90 | SMN1; SMN2 (0.46) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10699503 | 0.90 | PTGS2 (0.49) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10700688 | 0.85 | PTGS2 (0.52) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10700237 | 0.84 | PTGS2 (0.47) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL9678752 | 0.81 | RAB9A (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10701467 | 0.80 | CYP2E1 (0.56) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10703839 | 0.80 | SMN1; SMN2 (0.46) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10700028 | 0.80 | PTGS2 (0.43) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL9678554 | 0.79 | SMN1; SMN2 (0.58) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10699314 | 0.79 | SMN1; SMN2 (0.50) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | claimed |
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | disclosed |