Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11125937 | 0.90 | PKM (0.68) | PKMHSD17B1HTTPOLBAKR1B1 | |
| SCHEMBL10706677 | 0.87 | ALDH1A1 (0.52) | PKMHTTAKR1B1KMT2ASIRT1 | |
| SCHEMBL10704460 | 0.87 | SRD5A2 (0.52) | PKMPOLBAKR1B1SIRT1EGFR | |
| SCHEMBL10704144 | 0.87 | AKR1B1 (0.58) | AKR1B1KMT2AMEN1EGFRMAPT | |
| SCHEMBL10707197 | 0.84 | AKR1B1 (0.46) | PKMHSD17B1POLBAKR1B1SIRT1 | |
| SCHEMBL10706602 | 0.84 | SRD5A2 (0.50) | HSD17B1HTTAKR1B1KMT2AMEN1 | |
| SCHEMBL10706170 | 0.83 | PKM (0.46) | PKMHTTPOLBAKR1B1SIRT1 | |
| SCHEMBL10704392 | 0.80 | PTGDR2 (0.43) | PKMHTTAKR1B1SIRT1EGFR | |
| SCHEMBL10706137 | 0.79 | AKR1B1 (0.49) | POLBAKR1B1EGFRKDM4EMAPT | |
| SCHEMBL2581138 | 0.79 | KDM4E (0.57) | PKMHTTPOLBAKR1B1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150166-B1 | NOVEL ARYLACITIC ACID DERIVATIVES | PHARMACIA AB (SE) | 1988-07-20 | — | — | EP | disclosed |
| US-4695648-A | PROSTAGLANDIN DEHYDROGENASE INHIBITORS | PHARMACIA AB (SE) | 1987-09-22 | — | — | US | disclosed |
| EP-0168467-A1 | NOVEL ARYLACETIC ACID DERIVATIVES | PHARMACIA AB (SE) | 1986-01-22 | — | — | EP | disclosed |
| WO-1985003287-A1 | NOVEL ARYLACETIC ACID DERIVATIVES | PHARMACIA AB (SE) | 1985-08-01 | — | — | WO | disclosed |
| EP-0150166-A1 | Novel arylacitic acid derivatives | PHARMACIA AB (SE) | 1985-07-31 | — | — | EP | disclosed |