Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704144 | 0.87 | AKR1B1 (0.58) | AKR1B1EGFRLMNAMAPTTDP1 | |
| SCHEMBL10704460 | 0.87 | SRD5A2 (0.52) | AKR1B1EGFRSIRT1TSHRPKM | |
| SCHEMBL10704905 | 0.86 | AKR1B1 (0.46) | AKR1B1TSHRKDM4ELMNAMAPT | |
| SCHEMBL10706364 | 0.84 | PKM (0.56) | AKR1B1EGFRSIRT1TSHRPKM | |
| SCHEMBL10706677 | 0.84 | ALDH1A1 (0.52) | AKR1B1EGFRTTRSIRT1PKM | |
| SCHEMBL10706602 | 0.84 | SRD5A2 (0.50) | AKR1B1EGFRSIRT1TSHRLMNA | |
| SCHEMBL2443894 | 0.83 | AKR1B1 (0.55) | AKR1B1EGFRTTRTSHRKDM4E | |
| SCHEMBL24648555 | 0.83 | LMNA (0.52) | LTA4HTTRACHEKCNMA1PKM | |
| SCHEMBL10707394 | 0.82 | EGFR (0.48) | LTA4HEGFRTTRSIRT1KCNMA1 | |
| SCHEMBL10708148 | 0.81 | AKR1B1 (0.47) | AKR1B1EGFRACHETSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150166-B1 | NOVEL ARYLACITIC ACID DERIVATIVES | PHARMACIA AB (SE) | 1988-07-20 | — | — | EP | disclosed |
| US-4695648-A | PROSTAGLANDIN DEHYDROGENASE INHIBITORS | PHARMACIA AB (SE) | 1987-09-22 | — | — | US | disclosed |
| EP-0168467-A1 | NOVEL ARYLACETIC ACID DERIVATIVES | PHARMACIA AB (SE) | 1986-01-22 | — | — | EP | disclosed |
| WO-1985003287-A1 | NOVEL ARYLACETIC ACID DERIVATIVES | PHARMACIA AB (SE) | 1985-08-01 | — | — | WO | disclosed |