SCHEMBL10708355

SCHEMBL10708355

O=C(Cl)c1cc(C(=O)c2ccccc2)c(C(=O)Cl)c(C(=O)Cl)c1C(=O)Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C8 P10632 1/20 0.49
CYP2C9 P11712 1/20 0.49
AKR1C3 P42330 1/20 0.47
ALDH1A1 P00352 4/20 0.46
ATM Q13315 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
GAA P10253 2/20 0.44
MEN1 O00255 2/20 0.44
USP2 O75604 2/20 0.44
KMT2A Q03164 2/20 0.44
KDM4E B2RXH2 1/20 0.44
KEAP1 Q14145 1/20 0.44
NFE2L2 Q16236 1/20 0.44
MAPT P10636 2/20 0.44
POLB P06746 1/20 0.42
SRD5A2 P31213 1/20 0.41
NR4A1 P22736 1/20 0.41
PDE4A P27815 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9622204 0.79 AKR1C3 (0.53) AKR1C3ALDH1A1ATMTDP1L3MBTL1
SCHEMBL78316 0.78 AKR1C3 (0.68) CYP2C9AKR1C3ALDH1A1ATMTDP1
SCHEMBL31672209 0.78 AKR1C3 (0.68) CYP2C9AKR1C3ALDH1A1ATMTDP1
SCHEMBL7590892 0.76 ALDH1A1 (0.54) AKR1C3ALDH1A1ATMTDP1L3MBTL1
SCHEMBL30039122 0.74 BCAT2 (0.40) AKR1C3ALDH1A1MEN1KMT2A
SCHEMBL28824349 0.74 ALDH1A1 (0.38) ALDH1A1MAPTLMNA
SCHEMBL15549922 0.74 BCAT2 (0.40) AKR1C3ALDH1A1MEN1KMT2A
SCHEMBL76089 0.73 AKR1C3 (0.67) CYP2C8CYP2C9AKR1C3ALDH1A1ATM
SCHEMBL6890472 0.73 CA2 (0.50) CYP2C8CYP2C9AKR1C3ALDH1A1ATM
SCHEMBL8925670 0.73 SRD5A2 (0.40) CYP2C8CYP2C9ALDH1A1TDP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4590243-A USING ACYLLACTAM FUNCTIONAL MATERIALS MONSANTO COMPANY (US) 1986-05-20 US claimed
US-4590244-A CHEMICAL INTERMEDIATES FOR NYLON BLOCK POLYMERS MONSANTO COMPANY (US) 1986-05-20 US claimed
US-4581419-A POLYMERS HAVING HYDROXY END GROUPS MODIFIED BY A DICARBOXYLIC ACIDAND A LACTAM; NYLON MOLDING MATERIALS MONSANTO COMPANY (US) 1986-04-08 US claimed
EP-0067693-A1 Acid halide and acyllactam functional materials DSM RIM NYLON V.O.F (NL) 1982-12-22 EP claimed
EP-0067695-A1 Process for the preparaton of nylon block polymers DSM RIM NYLON V.O.F (NL) 1982-12-22 EP claimed
EP-0161549-B1 ACID HALIDE FUNCTIONAL MATERIALS DSM RIM NYLON V.O.F (NL) 1988-11-17 EP disclosed
US-4695383-A COPOLYAMIDE FROM A DIAMINODIPHENYL SULFONE TOYO BOSEKI KABUSHIKI KAISHA (JP) 1987-09-22 US disclosed
US-4649177-A Process for the preparation of nylon block polymers DM RIM NYLON VOF (NL) 1987-03-10 US disclosed
US-4645800-A Acyllactam functional materials DSM RIM NYLON VOF (NL) 1987-02-24 US disclosed
US-4628075-A PREPARATION OF NYLON BLOCK POLYMERS DSM RIM NYLON VOF (NL) 1986-12-09 US disclosed
EP-0067695-B1 PROCESS FOR THE PREPARATON OF NYLON BLOCK POLYMERS DSM RIM NYLON V.O.F (NL) 1986-10-15 EP disclosed
EP-0067693-B1 ACID HALIDE AND ACYLLACTAM FUNCTIONAL MATERIALS DSM RIM NYLON V.O.F (NL) 1986-09-10 EP disclosed
US-4590243-A USING ACYLLACTAM FUNCTIONAL MATERIALS MONSANTO COMPANY (US) 1986-05-20 US disclosed
US-4590244-A CHEMICAL INTERMEDIATES FOR NYLON BLOCK POLYMERS MONSANTO COMPANY (US) 1986-05-20 US disclosed
US-4581419-A POLYMERS HAVING HYDROXY END GROUPS MODIFIED BY A DICARBOXYLIC ACIDAND A LACTAM; NYLON MOLDING MATERIALS MONSANTO COMPANY (US) 1986-04-08 US disclosed
EP-0161549-A1 Acid halide functional materials DSM RIM NYLON V.O.F (NL) 1985-11-21 EP disclosed
EP-0067694-A1 Acid halide and acyllactam functional materials and process for the preparation of nylon block polymers therewith DSM RIM NYLON V.O.F (NL) 1982-12-22 EP disclosed
EP-0067693-A1 Acid halide and acyllactam functional materials DSM RIM NYLON V.O.F (NL) 1982-12-22 EP disclosed
EP-0067695-A1 Process for the preparaton of nylon block polymers DSM RIM NYLON V.O.F (NL) 1982-12-22 EP disclosed