Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1079384 | 0.75 | ALDH1A1 (0.35) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL5082319 | 0.74 | ALDH1A1 (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1070862 | 0.74 | KDM4E (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1078463 | 0.74 | KDM4E (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL28930333 | 0.72 | ALDH1A1 (0.58) | ALDH1A1IRAK4KDM4EALOX15TSHR | |
| Bromide SCHEMBL933202 | 0.72 | CYP1A2 (0.33) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1077104 | 0.72 | ALDH1A1 (0.33) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1070626 | 0.71 | KDM4E (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1071561 | 0.71 | KDM4E (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| SCHEMBL933207 | 0.70 | CYP1A2 (0.33) | ALDH1A1KDM4EALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027192-A1 | Process for Preparing Catalyst Systems Comprising Late Transition Metals | BASELL POLYOLEFINE GMBH (DE) | 2008-01-31 | — | — | US | disclosed |
| EP-1817349-A1 | PROCESS FOR PREPARING CATALYST SYSTEMS COMPRISING LATE TRANSITION METALS | Basell Polyolefine GmbH (DE) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006058746-A1 | PROCESS FOR PREPARING CATALYST SYSTEMS COMPRISING LATE TRANSITION METALS | BASELL POLYOLEFINE GMBH (DE) | 2006-06-08 | — | — | WO | disclosed |