Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.45 |
| ▸ | HINT1 | P49773 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10709133 | 0.95 | ADORA2A (0.42) | ADORA2AADORA2BADORA3ADORA1HINT1 | |
| SCHEMBL11015150 | 0.95 | ADORA2A (0.41) | ADORA2AADORA2BADORA3ADORA1HINT1 | |
| SCHEMBL10707941 | 0.93 | ADORA2A (0.42) | ADORA2AADORA2BADORA3ADORA1HINT1 | |
| SCHEMBL10709057 | 0.91 | ADORA2A (0.48) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL3450684 | 0.87 | ADORA3 (0.48) | ADORA2AADORA2BADORA3ADORA1MEN1 | |
| SCHEMBL10710910 | 0.86 | ADORA2A (0.46) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL10711083 | 0.83 | ADORA3 (0.45) | ADORA2AADORA2BADORA3ADORA1MEN1 | |
| SCHEMBL10711526 | 0.83 | HINT1 (0.39) | ADORA2AADORA2BADORA3ADORA1HINT1 | |
| SCHEMBL10712341 | 0.83 | ADORA3 (0.44) | ADORA2AADORA2BADORA3ADORA1MEN1 | |
| SCHEMBL10834196 | 0.82 | ADORA2A (0.40) | ADORA2AADORA2BADORA3ADORA1HINT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139358-B1 | N6-SUBSTITUTED DIARYLALKYL ADENOSINES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | WARNER-LAMBERT COMPANY (US) | 1988-11-09 | — | — | EP | claimed |
| EP-0175465-A1 | An association of, or composition comprising, haloperidol and a diphenylalkyl adenosine or a diphenylalkyl-2-amino adenosine | WARNER-LAMBERT COMPANY (US) | 1986-03-26 | — | — | EP | claimed |
| EP-0139358-A2 | N6-substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1985-05-02 | — | — | EP | claimed |
| EP-0139358-B1 | N6-SUBSTITUTED DIARYLALKYL ADENOSINES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | WARNER-LAMBERT COMPANY (US) | 1988-11-09 | — | — | EP | disclosed |
| EP-0175465-A1 | An association of, or composition comprising, haloperidol and a diphenylalkyl adenosine or a diphenylalkyl-2-amino adenosine | WARNER-LAMBERT COMPANY (US) | 1986-03-26 | — | — | EP | disclosed |
| EP-0139358-A2 | N6-substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1985-05-02 | — | — | EP | disclosed |