Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.57 |
| ▸ | PGR | P06401 | 4/20 | 0.57 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.57 |
| ▸ | KIF11 | P52732 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893991 | 0.89 | KIF11 (0.73) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL2054644 | 0.88 | AHR (0.56) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL25094235 | 0.88 | PGR (0.63) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL1903306 | 0.84 | KIF11 (0.80) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL3132725 | 0.80 | PGR (0.73) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL22340014 | 0.79 | BRD4 (0.56) | PDE3BPDE3AKIF11BRD4CREBBP | |
| SCHEMBL19538981 | 0.79 | AHR (0.53) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL27859220 | 0.79 | PDE3B (0.64) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL10711906 | 0.78 | PDE3B (0.68) | PDE3BPDE3AGRIA1PGRCACNG8 | |
| SCHEMBL1900155 | 0.78 | AHR (0.77) | PDE3BPDE3AGRIA1PGRCACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |