Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.80 |
| ▸ | TDP2 | O95551 | 2/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.54 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | AKT1 | P31749 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1396616 | 0.89 | KIF11 (1.00) | KIF11TDP2PDE3BPDE3ACYP1A2 | |
| SCHEMBL578303 | 0.88 | TDP2 (0.66) | KIF11TDP2PDE3BPDE3AGAA | |
| SCHEMBL31492431 | 0.88 | TDP2 (0.66) | KIF11TDP2PDE3BPDE3AGAA | |
| SCHEMBL1907965 | 0.88 | KIF11 (0.66) | KIF11TDP2PDE3BPDE3APGR | |
| SCHEMBL4898372 | 0.85 | KIF11 (0.72) | KIF11TDP2PDE3BPDE3APGR | |
| SCHEMBL4888861 | 0.85 | KIF11 (0.86) | KIF11TDP2PDE3BPDE3ACYP1A2 | |
| SCHEMBL4888035 | 0.85 | KIF11 (0.86) | KIF11TDP2PDE3BPDE3ACYP1A2 | |
| SCHEMBL1902698 | 0.84 | KIF11 (0.59) | KIF11TDP2PDE3BPDE3APGR | |
| SCHEMBL10712333 | 0.84 | PDE3B (0.62) | KIF11TDP2PDE3BPDE3APGR | |
| SCHEMBL4596516 | 0.84 | KIF11 (0.70) | KIF11TDP2PDE3BPDE3APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056985-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-05-12 | — | — | WO | disclosed |