Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.77 |
| ▸ | PGR | P06401 | 4/20 | 0.77 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
| ▸ | TDP2 | O95551 | 3/20 | 0.66 |
| ▸ | CMA1 | P23946 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.58 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154614 | 0.87 | AHR (1.00) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL28203333 | 0.87 | PGR (1.00) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL3519711 | 0.87 | PGR (1.00) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL3307966 | 0.86 | KIF11 (0.68) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL1896888 | 0.85 | TDP2 (0.70) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL18189562 | 0.84 | AHR (0.69) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL3132725 | 0.84 | PGR (0.73) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL1900635 | 0.83 | PDE3B (0.64) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL1897593 | 0.82 | PDE3B (0.68) | AHRPGRPDE3BPDE3ATDP2 | |
| SCHEMBL10711906 | 0.82 | PDE3B (0.68) | AHRPGRPDE3BPDE3ATDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056985-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-05-12 | — | — | WO | disclosed |
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |