SCHEMBL10713698

SCHEMBL10713698

Nc1ccc(Oc2ccc(C(c3ccc(Oc4ccc(N)cc4)c(Cl)c3)(C(F)(F)F)C(F)(F)F)cc2Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE7A Q13946 2/20 0.50
FFAR1 O14842 5/20 0.46
RAB9A P51151 3/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
MAPT P10636 4/20 0.41
ALDH1A1 P00352 3/20 0.41
HPGD P15428 2/20 0.41
NPC1 O15118 2/20 0.41
MAPK1 P28482 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
TDP1 Q9NUW8 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
TTR P02766 1/20 0.40
PPOX P50336 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.40
LMNA P02545 1/20 0.40
ATM Q13315 1/20 0.40
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3842060 0.91 PDE7A (0.47) PDE7AFFAR1RAB9AL3MBTL1MAPT
SCHEMBL9582439 0.88 FFAR1 (0.58) PDE7AFFAR1RAB9AL3MBTL1MAPT
SCHEMBL27714446 0.84 L3MBTL1 (0.59) PDE7ARAB9AL3MBTL1MAPTALDH1A1
SCHEMBL2890447 0.83 RAB9A (0.47) FFAR1RAB9AL3MBTL1MAPTALDH1A1
SCHEMBL28639356 0.82 RAB9A (0.42) RAB9AL3MBTL1MAPTALDH1A1HPGD
SCHEMBL10714102 0.82 RAB9A (0.42) PDE7ARAB9AL3MBTL1MAPTALDH1A1
SCHEMBL30172875 0.82 RAB9A (0.42) RAB9AL3MBTL1MAPTALDH1A1HPGD
SCHEMBL2509666 0.81 PDE7A (0.52) PDE7AFFAR1RAB9AL3MBTL1MAPT
SCHEMBL10715067 0.81 MAOB (0.43) PDE7ARAB9AMAPTALDH1A1HPGD
SCHEMBL11095176 0.79 FFAR1 (0.65) FFAR1RAB9AL3MBTL1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4758875-A Resin encapsulated semiconductor device HITACHI, LTD. (JP) 1988-07-19 US disclosed