Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | KYNU | Q16719 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14376753 | 0.82 | F2 (0.63) | ELANEF2PLAUPLAT | |
| SCHEMBL10717446 | 0.82 | CTSB (0.52) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL10717382 | 0.81 | CTSL (0.52) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7299710 | 0.80 | CTSK (0.65) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL7331686 | 0.80 | CTSK (0.65) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL22225460 | 0.79 | CTSK (0.61) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL10718394 | 0.79 | ACE2 (0.58) | — | |
| SCHEMBL10716415 | 0.79 | CTSB (0.49) | CTSBCTSLCTSSCTSKCASP1 | |
| SCHEMBL10715965 | 0.79 | ACE2 (0.53) | CTSBCTSLCTSSCTSK | |
| SCHEMBL7286488 | 0.78 | CTSS (0.46) | CTSBCTSLCTSSCTSKREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0209848-A2 | Enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |