Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10718981 | 0.80 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL10716611 | 0.76 | NAMPT (0.54) | ALDH1A1SMN1; SMN2HPGDPOLBMEN1 | |
| SCHEMBL1169464 | 0.75 | PRMT1 (0.74) | ALDH1A1SMN1; SMN2GAAPOLBTSHR | |
| SCHEMBL12530900 | 0.72 | PTGS1 (0.60) | ALDH1A1SMN1; SMN2HPGDALOX15HSD17B10 | |
| SCHEMBL4636274 | 0.70 | KDM4E (0.54) | ALDH1A1SMN1; SMN2HPGDALOX15HSD17B10 | |
| SCHEMBL1830012 | 0.70 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2HPGDALOX15HSD17B10 | |
| SCHEMBL1830014 | 0.70 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2HPGDALOX15HSD17B10 | |
| SCHEMBL19416501 | 0.68 | TP53 (0.61) | ALDH1A1SMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL10718848 | 0.68 | KDM4E (0.44) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL399162 | 0.67 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2HPGDGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |