Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CFD | P00746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072204 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1SRD5A2CYP1A2CYP2C9 | |
| SCHEMBL951357 | 0.86 | ALDH1A1 (0.59) | KDM4EALDH1A1SRD5A2CYP1A2CYP2C9 | |
| SCHEMBL951355 | 0.86 | ALDH1A1 (0.59) | KDM4EALDH1A1SRD5A2CYP1A2CYP2C9 | |
| SCHEMBL30407949 | 0.81 | FLT3 (0.43) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL5360581 | 0.81 | ATP6V1B1 (0.51) | KDM4ESRD5A2CYP1A2CYP2C9HPGD | |
| SCHEMBL5360579 | 0.81 | ATP6V1B1 (0.51) | KDM4ESRD5A2CYP1A2CYP2C9HPGD | |
| SCHEMBL1745452 | 0.79 | GSK3B (0.67) | KDM4EMAOBGSK3BBACE1SLC5A1 | |
| SCHEMBL19079051 | 0.79 | GSK3B (0.67) | KDM4EMAOBGSK3BBACE1SLC5A1 | |
| SCHEMBL5947111 | 0.79 | GSK3B (0.67) | KDM4EMAOBGSK3BBACE1SLC5A1 | |
| SCHEMBL16971179 | 0.79 | HDAC8 (0.49) | KDM4EALDH1A1SRD5A2MAOBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |