Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10914337 | 0.90 | MAPT (0.53) | MAPTHPGDPOLBALDH1A1KMT2A | |
| SCHEMBL10913886 | 0.84 | KDM4E (0.50) | MAPTGAAHPGDPOLBALDH1A1 | |
| SCHEMBL10915430 | 0.81 | ALDH1A1 (0.46) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10914093 | 0.79 | ALDH1A1 (0.46) | MAPTPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL6221292 | 0.77 | POLB (0.54) | MAPTGAAHPGDPOLBALDH1A1 | |
| SCHEMBL10377541 | 0.74 | NPC1 (0.50) | MAPTPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL10377358 | 0.74 | NPC1 (0.50) | MAPTPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL6960006 | 0.71 | ALDH1A1 (0.54) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6960011 | 0.71 | ALDH1A1 (0.54) | MAPTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8558794 | 0.71 | MAPT (0.48) | MAPTGAAHPGDPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236902-A1 | 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-substituted-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |