Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558794 | 0.83 | MAPT (0.48) | POLBGAAMAPTHPGDL3MBTL1 | |
| SCHEMBL98711 | 0.77 | SLC29A1 (0.53) | POLBGAAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL10724090 | 0.77 | MAPT (0.49) | POLBGAAMAPTHPGDL3MBTL1 | |
| SCHEMBL10913886 | 0.76 | KDM4E (0.50) | POLBGAAMAPTHPGDL3MBTL1 | |
| SCHEMBL98665 | 0.74 | RAB9A (0.50) | POLBGAAMAPTHPGDL3MBTL1 | |
| SCHEMBL28070731 | 0.73 | APP (0.60) | GAAMAPTHPGDSMN1; SMN2KMT2A | |
| SCHEMBL23486013 | 0.71 | MEN1 (0.47) | GAAMAPTHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL5654152 | 0.70 | MAPT (1.00) | POLBGAAMAPTHPGDL3MBTL1 | |
| SCHEMBL1304880 | 0.70 | MAPT (0.52) | POLBGAAMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL14426679 | 0.69 | SMN1; SMN2 (0.92) | GAAMAPTHPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |