Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19756640 | 0.79 | ALDH1A1 (0.42) | PDGFRBPDGFRAMAPTTSHRALDH1A1 | |
| SCHEMBL14673728 | 0.79 | MAPT (0.41) | PDGFRBPDGFRAMAPTTSHRALDH1A1 | |
| SCHEMBL16009860 | 0.76 | MAOA (0.42) | MAPTTSHRALDH1A1KEAP1KDM4E | |
| SCHEMBL11310484 | 0.73 | MAPT (0.44) | MAPTTSHRALDH1A1KDM4ENPC1 | |
| SCHEMBL10726158 | 0.73 | CYP2C9 (0.47) | MAPTTSHRALDH1A1KDM4E | |
| SCHEMBL10368828 | 0.72 | CA12 (0.42) | MAPTTSHRALDH1A1KDM4ECA2 | |
| SCHEMBL4803345 | 0.72 | MAPT (0.40) | PDGFRBPDGFRAMAPTTSHRALDH1A1 | |
| SCHEMBL15018567 | 0.72 | ACHE (0.43) | PDGFRBPDGFRAMAPTTSHRALDH1A1 | |
| SCHEMBL11009295 | 0.71 | SMN1; SMN2 (0.42) | ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL10729810 | 0.71 | HPGD (0.38) | TSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672138-A | INTERMEDIATES FOR BENZO (B) THIOPHENES; HYPOTENSIVE AGENTS, DIURETICS | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0050326-B1 | BENZO(B)THIOPHENES | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-01-29 | — | — | EP | disclosed |
| EP-0155981-A2 | Derivatives of alkoxythiophenol; alkoxyphenolthio carbamates | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4537976-A | Benzo[b]thiophenes | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-08-27 | — | — | US | disclosed |
| US-4528399-A | Benzo[b]thiophenes intermediates | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4436748-A | HYPOTENSIVES, DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1984-03-13 | — | — | US | disclosed |
| EP-0050326-A2 | Benzo(b)thiophenes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-04-28 | — | — | EP | disclosed |