Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.61 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020516 | 0.78 | PDE3B (0.49) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10650666 | 0.78 | PDE3B (0.49) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10647873 | 0.78 | PBRM1 (0.48) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11020513 | 0.78 | PDE3B (0.49) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7280962 | 0.76 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10724467 | 0.76 | PDE3B (0.47) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL13464716 | 0.75 | SMN1; SMN2 (0.50) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10648314 | 0.75 | PDE3B (0.60) | PDE3BPDE3APDE2APDE4BPDE4A | |
| SCHEMBL10806820 | 0.74 | PDE3B (0.46) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10726907 | 0.74 | PDE3B (0.45) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |