Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924482 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10726946 | 0.75 | PDE3B (0.61) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10730685 | 0.73 | SMN1; SMN2 (0.38) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10650242 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10650666 | 0.73 | PDE3B (0.49) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL8478610 | 0.72 | GPR119 (0.56) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10648684 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10650433 | 0.72 | HRH3 (0.46) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL10724280 | 0.72 | MAPT (0.38) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL11035016 | 0.71 | SMN1; SMN2 (0.68) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012142125-A2 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-10-18 | — | — | WO | disclosed |