Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10727054 | 0.92 | TAAR1 (0.36) | TAAR1HTR1A | |
| SCHEMBL10724402 | 0.87 | TAAR1 (0.35) | TAAR1HTR1APDE4BPDE3BPDE3A | |
| SCHEMBL10724228 | 0.79 | CA12 (0.39) | TAAR1HTR1APDE4BMEN1ALDH1A1 | |
| SCHEMBL10968242 | 0.74 | SMN1; SMN2 (0.38) | TAAR1HTR1APDE4BPDE3BPDE3A | |
| SCHEMBL10730627 | 0.74 | CYP11B1 (0.48) | PDE4BPDE3BPDE3AALDH1A1 | |
| SCHEMBL11114157 | 0.66 | PDE3B (0.47) | TAAR1HTR1APDE4BPDE3BPDE3A | |
| SCHEMBL11242032 | 0.65 | PDE4B (0.51) | PDE4BPDE3BPDE3AMEN1ALDH1A1 | |
| SCHEMBL10727048 | 0.65 | CYP11B1 (0.50) | ALDH1A1 | |
| SCHEMBL13656416 | 0.62 | ALDH1A1 (0.40) | PDE4BPDE3BPDE3AMEN1ALDH1A1 | |
| SCHEMBL13656430 | 0.62 | PDE4B (0.43) | PDE4BPDE3BPDE3AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |