Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566304 | 0.72 | ERN1 (0.59) | THRBTDP2MAPTKDM4EHSD17B10 | |
| SCHEMBL10567603 | 0.72 | KDM4E (0.42) | THRBTDP2MAPTKDM4EALDH1A1 | |
| SCHEMBL10568294 | 0.71 | TSHR (0.50) | THRBTDP2MAPTKDM4EALDH1A1 | |
| SCHEMBL14893220 | 0.70 | ADORA2A (0.60) | THRBHSD17B10MEN1KMT2AADORA2B | |
| SCHEMBL25090458 | 0.68 | ADORA2A (0.75) | KDM4EADORA2B | |
| SCHEMBL11577500 | 0.68 | KDM4E (0.48) | TDP2MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL28860150 | 0.67 | HTR2A (0.48) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10688020 | 0.67 | TDP2 (0.54) | THRBTDP2MAPTKDM4EALDH1A1 | |
| SCHEMBL10565642 | 0.67 | PRKCA (0.44) | THRBTDP2MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11577680 | 0.67 | KDM4E (0.47) | TDP2MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4649142-A | 3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)-pyrimidinone useful as cardiotonic agent and anti-allergic agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-10 | — | — | US | disclosed |
| EP-0166564-A2 | Pyrimidone derivatives, preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-02 | — | — | EP | disclosed |