Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254783 | 0.82 | MEN1 (0.43) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10727334 | 0.80 | KDM4E (0.47) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11254789 | 0.79 | MEN1 (0.40) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10746185 | 0.79 | ALDH1A1 (0.70) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10566344 | 0.77 | RAB9A (0.41) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10730613 | 0.76 | SMN1; SMN2 (0.52) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6956520 | 0.75 | ALDH1A1 (0.64) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4384277 | 0.75 | ALDH1A1 (0.64) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL744307 | 0.74 | ALDH1A1 (0.48) | MAPTHTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29351076 | 0.74 | ALDH1A1 (0.48) | MAPTHTTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4699984-A | Preparation of intermediates to 6-fluoro-7-(2,6-dimethylpyridyl)quinoline carboxylic acids and compounds | STERLING DRUG INC. (US) | 1987-10-13 | — | — | US | disclosed |
| US-4698350-A | 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof | STERLING DRUG INC. (US) | 1987-10-06 | — | — | US | disclosed |
| EP-0179239-A2 | 7-(Pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid having antibacterial activity and preparation thereof | STERLING DRUG INC. (US) | 1986-04-30 | — | — | EP | disclosed |