Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | THPO | P40225 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1149912 | 1.00 | TSHR (0.97) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL30038829 | 1.00 | TSHR (0.97) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL10619504 | 0.99 | TSHR (1.00) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL17978414 | 0.99 | TSHR (1.00) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL6368864 | 0.97 | TSHR (0.93) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL5280630 | 0.77 | TSHR (0.61) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL5280636 | 0.77 | TSHR (0.61) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL11706811 | 0.76 | TSHR (0.64) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| Hydrochloric Acid SCHEMBL11706807 | 0.76 | TSHR (0.64) | TSHRCYP3A4CYP2D6THPOPMP22 | |
| SCHEMBL22402644 | 0.74 | CYP3A4 (0.57) | TSHRCYP3A4CYP2D6THPOPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011001258-A1 | COMPOSITIONS, METHODS, AND KITS FOR TREATING VIRAL AND BACTERIAL INFECTIONS BY TOCOTRIENOLS, TOCOMONOENOLS, TOCODIENOLS, TOCOPHEROLS, AND THEIR DERIVATES | EVITA LIFE SCIENCE PTE. LTD (SG) | 2011-01-06 | — | — | WO | disclosed |
| WO-2010095041-A2 | COMPOSITIONS, METHODS, AND KITS FOR TREATING INFLUENZA VIRAL INFECTIONS | EXCRX (SINGAPORE) PTE.LTD. (SG) | 2010-08-26 | — | — | WO | disclosed |
| US-20090012067-A1 | Modulation of Hypothalamic Atp-Sensitive Potassium Channels | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2009-01-08 | — | — | US | disclosed |
| US-20070026079-A1 | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels | DARA BIOSCIENCES, INC. | 2007-02-01 | — | — | US | disclosed |
| WO-2006119295-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | COMBINATORX, INCORPORATED (US) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012067-A1 | Modulation of Hypothalamic Atp-Sensitive Potassium Channels | PYGB, PC, KCNN3 | TSHR 1776/4885CYP3A4 2037/4885CYP2D6 3146/4885 |
| US-20070026079-A1 | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels | PC, LIPE, ATP5ME | TSHR 1157/4885CYP3A4 3579/4885CYP2D6 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.