Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20854469 | 0.74 | METAP2 (0.53) | CA12CA9METAP2ALOX15HSD17B10 | |
| SCHEMBL23143475 | 0.73 | CYP11B2 (0.44) | HTR2CCYP11B2 | |
| SCHEMBL9674642 | 0.73 | METAP2 (0.47) | METAP2HSD17B10MAPK8PLK4CDK2 | |
| SCHEMBL30096606 | 0.71 | CA12 (0.40) | CA12CA9METAP2ALOX15HSD17B10 | |
| SCHEMBL20503690 | 0.71 | CA12 (0.40) | CA12CA9METAP2ALOX15HSD17B10 | |
| SCHEMBL10740285 | 0.71 | MAOB (0.47) | CA12CA9METAP2ALOX15HSD17B10 | |
| Dihydrophenanthridine SCHEMBL2087461 | 0.71 | CA12 (0.56) | CA12CA9ALOX15HSD17B10GAA | |
| Dihydrophenanthridine SCHEMBL29791568 | 0.71 | CA12 (0.56) | CA12CA9ALOX15HSD17B10GAA | |
| SCHEMBL23143476 | 0.70 | DRD4 (0.47) | MAOBCYP11B2 | |
| SCHEMBL30704654 | 0.70 | CA12 (0.46) | CA12CA9METAP2ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4716159-A | Pyridazino[4,3-c]-isoquinolines having anti-anxiety activity | GRUPPO LEPETIT, S.P.A. (IT) | 1987-12-29 | — | — | US | disclosed |
| EP-0134461-B1 | PYRIDAZINO(4,3-C)ISOQUINOLINE DERIVATIVES | GRUPPO LEPETIT S.p.A. (IT) | 1987-10-07 | — | — | EP | disclosed |
| EP-0134461-A1 | Pyridazino(4,3-c)isoquinoline derivatives | GRUPPO LEPETIT S.p.A. (IT) | 1985-03-20 | — | — | EP | disclosed |