Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23143475 | 0.84 | CYP11B2 (0.44) | KDM4EMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23143476 | 0.81 | DRD4 (0.47) | MAPTTSHRMAOACYP19A1BCHE | |
| SCHEMBL17264315 | 0.78 | CHRNB2 (0.37) | MAOACYP19A1TNFCDK1CDK2 | |
| SCHEMBL17264314 | 0.76 | TDP1 (0.33) | KDM4EMEN1KMT2ALMNA | |
| SCHEMBL30322896 | 0.75 | MEN1 (0.47) | METAP2KDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL69894 | 0.75 | MEN1 (0.47) | METAP2KDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL30276323 | 0.74 | KMT2A (0.46) | KDM4EMAPTSMN1; SMN2MEN1CYP2D6 | |
| SCHEMBL10735470 | 0.73 | CA12 (0.46) | METAP2HSD17B10MAPK8MAPK9MAPK10 | |
| SCHEMBL70512 | 0.72 | METAP2 (0.47) | METAP2KDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7292209 | 0.71 | KDR (0.43) | SMN1; SMN2MEN1CYP2D6KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110845481-B | 3,4-diazafluorene derivatives, method for synthesizing same, and electronic device containing 3,4-diazafluorene derivatives | 苏州久显新材料有限公司 | 2023-04-18 | — | — | CN | claimed |
| CN-110845481-A | 3, 4-diazafluorene derivatives, method for synthesizing the same, and electronic devices containing the same | 苏州久显新材料有限公司 | 2020-02-28 | — | — | CN | claimed |
| CN-102002003-A | Class I diazafluorenone, fluorene and spiro-fluorene derivative, and preparation method and application thereof | UNIV EAST CHINA NORMAL | 2011-04-06 | — | — | CN | claimed |
| CN-110845481-B | 3,4-diazafluorene derivatives, method for synthesizing same, and electronic device containing 3,4-diazafluorene derivatives | 苏州久显新材料有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-110845481-B | 3,4-diazafluorene derivatives, method for synthesizing same, and electronic device containing 3,4-diazafluorene derivatives | 苏州久显新材料有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-110845481-B | 3,4-diazafluorene derivatives, method for synthesizing same, and electronic device containing 3,4-diazafluorene derivatives | 苏州久显新材料有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-110845481-A | 3, 4-diazafluorene derivatives, method for synthesizing the same, and electronic devices containing the same | 苏州久显新材料有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-110845481-A | 3, 4-diazafluorene derivatives, method for synthesizing the same, and electronic devices containing the same | 苏州久显新材料有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-110845481-A | 3, 4-diazafluorene derivatives, method for synthesizing the same, and electronic devices containing the same | 苏州久显新材料有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-102002003-A | Class I diazafluorenone, fluorene and spiro-fluorene derivative, and preparation method and application thereof | UNIV EAST CHINA NORMAL | 2011-04-06 | — | — | CN | disclosed |
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0137333-A2 | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase | ALCON LABORATORIES, INC. (US) | 1985-04-17 | — | — | EP | disclosed |