SCHEMBL20503690

SCHEMBL20503690

c1ccc2c(c1)CNc1ccccc1-c1[nH]nnc1-2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 2/20 0.40
▸ CA9 Q16790 2/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ JAK2 O60674 1/20 0.38
▸ GAA P10253 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ METAP2 P50579 1/20 0.36
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ HSD17B3 P37058 1/20 0.33
▸ NOS2 P35228 1/20 0.33
▸ CDK1 P06493 1/20 0.33
▸ CDK2 P24941 1/20 0.33
▸ MAPK8 P45983 2/20 0.33
▸ MAPK9 P45984 2/20 0.33
▸ MAPK10 P53779 1/20 0.33
▸ PLK4 O00444 1/20 0.33
▸ DAPK3 O43293 1/20 0.33
▸ PIM1 P11309 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30096606 1.00 CA12 (0.40) CA12CA9ALOX15HSD17B10JAK2
SCHEMBL30340726 0.94 CA12 (0.40) CA12CA9ALOX15HSD17B10JAK2
SCHEMBL17949690 0.94 CA12 (0.40) CA12CA9ALOX15HSD17B10JAK2
SCHEMBL23044043 0.78 KDM4E (0.41) METAP2MAPK8MAPK9MAPK10PLK4
SCHEMBL21340386 0.76 ACVR1 (0.39) GAACDK1CDK2PDGFRALTK
SCHEMBL20854469 0.75 METAP2 (0.53) CA12CA9ALOX15HSD17B10JAK2
Dihydrophenanthridine SCHEMBL29791568 0.73 CA12 (0.56) CA12CA9ALOX15HSD17B10JAK2
Dihydrophenanthridine SCHEMBL2087461 0.73 CA12 (0.56) CA12CA9ALOX15HSD17B10JAK2
SCHEMBL24976109 0.73 ALDH1A1 (0.37) HSD17B10GAACDK1CDK2MAPK8
SCHEMBL727511 0.73 ALDH1A1 (0.37) HSD17B10GAACDK1CDK2MAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096366-A1 CONJUGATES FOR DELIVERY ACROSS THE BLOOD BRAIN BARRIER ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2025-05-08 — — WO claimed
US-20250228954-A1 Designing Antisense Oligonucleotide Delivery Peptides by Interpretable Machine Learning SAREPTA THERAPEUTICS INC (US) 2025-07-17 — — US disclosed
US-20250171776-A1 NON-CANONICAL CELL-PENETRATING PEPTIDES FOR ANTISENSE OLIGOMER DELIVERY SAREPTA THERAPEUTICS, INC. (US) 2025-05-29 — — US disclosed
US-20250161469-A1 TRIMERIC PEPTIDES FOR ANTISENSE DELIVERY SAREPTA THERAPEUTICS, INC. 2025-05-22 — — US disclosed
WO-2025096366-A1 CONJUGATES FOR DELIVERY ACROSS THE BLOOD BRAIN BARRIER ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2025-05-08 — — WO disclosed
WO-2025030099-A1 NON-CANONICAL CELL-PENETRATING PEPTIDES FOR ANTISENSE OLIGOMER DELIVERY SAREPTA THERAPEUTICS, INC. (US) 2025-02-06 — — WO disclosed
US-20250011777-A1 DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2025-01-09 — — US disclosed
US-12168059-B2 Trimeric peptides for antisense delivery SAREPTA THERAPEUTICS, INC. (US) 2024-12-17 — — US disclosed
US-20240318179-A1 MORPHOLINO OLIGOMERS FOR TREATMENT OF PERIPHERAL MYELIN PROTEIN 22 RELATED DISEASES SAREPTA THERAPEUTICS, INC. 2024-09-26 — — US disclosed
EP-4387676-A2 DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES Sarepta Therapeutics, Inc. (US) 2024-06-26 — — EP disclosed
US-20230020297-A1 UOX-ALBUMIN CONJUGATE WITH CERTAIN NUMBERS OF ALBUMIN CONJUGATED THERETO, AND MANUFACTURING METHOD THEREOF PROABTECH CO., LTD. (KR) 2023-01-19 — — US disclosed
EP-3936501-A1 SITE-SPECIFIC ANTIBODY CONJUGATION AND ANTIBODY-DRUG CONJUGATE AS SPECIFIC EXAMPLE THEREOF ABTIS Co., Ltd. (KR) 2022-01-12 — — EP disclosed
EP-3157571-B1 FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES NOVARTIS AG (CH) 2021-11-24 — — EP disclosed
US-20210290772-A1 TRIMERIC PEPTIDES FOR ANTISENSE DELIVERY SAREPTA THERAPEUTICS, INC. 2021-09-23 — — US disclosed
WO-2021150867-A1 DESIGNING ANTISENSE OLIGONUCLEOTIDE DELIVERY PEPTIDES BY INTERPRETABLE MACHINE LEARNING SAREPTA THERAPEUTICS, INC. (US) 2021-07-29 — — WO disclosed
EP-3829597-A1 TRIMERIC PEPTIDES FOR ANTISENSE DELIVERY Sarepta Therapeutics, Inc. (US) 2021-06-09 — — EP disclosed
WO-2021067458-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) 2021-04-08 — — WO disclosed
WO-2020028254-A1 TRIMERIC PEPTIDES FOR ANTISENSE DELIVERY SAREPTA THERAPEUTICS, INC. (US) 2020-02-06 — — WO disclosed
EP-3082877-B1 CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF NOVARTIS AG (CH) 2019-08-28 — — EP disclosed
EP-3377112-A1 CHEMICALLY-LOCKED BISPECIFIC ANTIBODIES Sorrento Therapeutics, Inc. (US) 2018-09-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12168059-B2 Trimeric peptides for antisense delivery MTPN, MYOF, IAPP CA12 2137/4885CA9 3231/4885ALOX15 4136/4885
US-20250011777-A1 DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES MYOF, IAPP, MTPN CA12 2588/4885CA9 4084/4885ALOX15 3698/4885
US-20250171776-A1 NON-CANONICAL CELL-PENETRATING PEPTIDES FOR ANTISENSE OLIGOMER DELIVERY MYOF, TNNC1, MTPN CA12 3111/4885CA9 3474/4885ALOX15 2687/4885
US-20230020297-A1 UOX-ALBUMIN CONJUGATE WITH CERTAIN NUMBERS OF ALBUMIN CONJUGATED THERETO, AND MANUFACTURING METHOD THEREOF DAO, ALB, DDO CA12 2918/4885CA9 2342/4885ALOX15 74/4885
US-20210290772-A1 TRIMERIC PEPTIDES FOR ANTISENSE DELIVERY MTPN, MYOF, IAPP CA12 2137/4885CA9 3231/4885ALOX15 4136/4885
US-20250161469-A1 TRIMERIC PEPTIDES FOR ANTISENSE DELIVERY MTPN, MYOF, IAPP CA12 2137/4885CA9 3240/4885ALOX15 4120/4885
US-20250228954-A1 Designing Antisense Oligonucleotide Delivery Peptides by Interpretable Machine Learning MTPN, TNNC1, MYOF CA12 2624/4885CA9 3486/4885ALOX15 3549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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