Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.41 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5958796 | 0.79 | TDP1 (0.65) | MAPTTDP1ABCC8KCNJ11ALDH1A1 | |
| SCHEMBL12570849 | 0.76 | TSHR (0.60) | MAPTTDP1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL10731117 | 0.74 | ABCC8 (0.53) | MAPTTDP1ABCC8KCNJ11ALDH1A1 | |
| SCHEMBL266568 | 0.73 | — | — | |
| SCHEMBL8809569 | 0.73 | MAPT (0.52) | MAPTTDP1ABCC8KCNJ11ALDH1A1 | |
| SCHEMBL17785663 | 0.72 | TDP1 (0.42) | MAPTTDP1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL4654523 | 0.71 | GUSB (0.56) | TDP1ALDH1A1SMN1; SMN2HPGDMAPK1 | |
| SCHEMBL10748570 | 0.71 | PTPRC (0.58) | MAPTTDP1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL28366256 | 0.70 | ACHE (0.57) | MAPTTDP1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL27986193 | 0.70 | NPBWR1 (0.55) | MAPTTDP1ALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239191-A2 | Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-30 | — | — | EP | disclosed |