Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 5/20 | 0.45 |
| ▸ | NFKBIA | P25963 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15658709 | 0.75 | GUSB (0.67) | GUSBMEN1KMT2ATDP1SLC40A1 | |
| SCHEMBL46669 | 0.73 | CA1 (0.59) | GUSBMEN1KMT2ATDP1NPC1 | |
| SCHEMBL8422362 | 0.73 | SMN1; SMN2 (0.72) | GUSBMEN1KMT2ATDP1MCL1 | |
| SCHEMBL26931604 | 0.72 | GUSB (0.63) | GUSBMEN1KMT2ATDP1L3MBTL1 | |
| SCHEMBL8425835 | 0.72 | MEN1 (0.56) | GUSBRELANFKBIAMEN1KMT2A | |
| SCHEMBL15661006 | 0.72 | ALDH1A1 (0.61) | GUSBRELAMEN1KMT2ATDP1 | |
| SCHEMBL7015594 | 0.71 | GUSB (0.66) | GUSBMEN1KMT2AMCL1NPC1 | |
| SCHEMBL10736544 | 0.71 | MAPT (0.50) | MEN1KMT2ATDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8426004 | 0.70 | GAA (0.57) | GUSBMEN1KMT2ANHERF1MCL1 | |
| SCHEMBL7014839 | 0.70 | GUSB (0.56) | GUSBMEN1KMT2ATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |