Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10738457 | 0.89 | KMT2A (0.48) | MAPTRAB9AHTTKMT2AMEN1 | |
| SCHEMBL10736825 | 0.89 | MAPT (0.41) | MAPTRAB9AHTTKMT2AMEN1 | |
| SCHEMBL10733258 | 0.87 | RAB9A (0.45) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL10739797 | 0.83 | CYP2D6 (0.47) | MAPTRAB9AHTTKMT2AMEN1 | |
| SCHEMBL10737468 | 0.83 | MAPT (0.45) | MAPTRAB9AHTTKMT2ANPC1 | |
| SCHEMBL10739911 | 0.82 | KDM4E (0.39) | MAPTRAB9AHTTNPC1ALDH1A1 | |
| SCHEMBL10964112 | 0.79 | ALDH1A1 (0.39) | MAPTRAB9AHTTKMT2AMEN1 | |
| SCHEMBL11899473 | 0.79 | MAPT (0.43) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL30554021 | 0.77 | KCNJ1 (0.51) | MAPTRAB9AHTTKMT2AMEN1 | |
| SCHEMBL30554031 | 0.76 | SMN1; SMN2 (0.58) | MAPTRAB9ANPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4686219-A | 11-(Piperazin- or homopiperazin-1-yl)-5H-imidazo-(2,1-C)(1,4)benzodiazepines useful as anti-allergics | BOEHRINGER INGELHEIM KG (DE) | 1987-08-11 | — | — | US | disclosed |