Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | USP10 | Q14694 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10737356 | 0.89 | MAPT (0.41) | MAPTLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL10738457 | 0.87 | KMT2A (0.48) | MAPTLMNAHTTALDH1A1RAB9A | |
| SCHEMBL10733258 | 0.84 | RAB9A (0.45) | MAPTSMN1; SMN2ALDH1A1RAB9AMEN1 | |
| SCHEMBL10739935 | 0.83 | ALDH1A1 (0.41) | MAPTLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL10739797 | 0.80 | CYP2D6 (0.47) | MAPTLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL10737468 | 0.80 | MAPT (0.45) | MAPTLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL30554021 | 0.75 | KCNJ1 (0.51) | MAPTLMNAHTTRAB9AMEN1 | |
| SCHEMBL29848981 | 0.73 | ALDH1A1 (0.52) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL19783798 | 0.73 | ALDH1A1 (0.52) | MAPTLMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL21395564 | 0.72 | LMNA (0.56) | MAPTLMNASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4686219-A | 11-(Piperazin- or homopiperazin-1-yl)-5H-imidazo-(2,1-C)(1,4)benzodiazepines useful as anti-allergics | BOEHRINGER INGELHEIM KG (DE) | 1987-08-11 | — | — | US | disclosed |