Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10745926 | 0.82 | CYP2C9 (0.40) | CHEK1PDE3BPDE3ACYP1A2PDE1A | |
| SCHEMBL10744610 | 0.82 | PARP10 (0.49) | CHEK1PDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL11069723 | 0.80 | LMNA (0.44) | CHEK1PDE3BPDE3APDE2APDE1A | |
| SCHEMBL10744197 | 0.80 | KDM4E (0.41) | ALDH1A1MAPTKDM4EGAAPKM | |
| SCHEMBL10747539 | 0.78 | ADORA3 (0.50) | CHEK1PDE3BPDE3APDE1APDE1B | |
| SCHEMBL10745104 | 0.77 | KDM4E (0.40) | ALDH1A1MAPTKDM4EGAAPOLB | |
| SCHEMBL10745368 | 0.77 | CYP1A2 (0.40) | PDE2ACYP1A2ALDH1A1MAPTNPSR1 | |
| SCHEMBL10742951 | 0.77 | KDM4E (0.42) | CHEK1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL10746913 | 0.76 | PARP10 (0.49) | CHEK1PDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL14492324 | 0.76 | CHEK1 (0.47) | CHEK1PDE3BPDE3APDE2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668678-A | ANTIALLERGENS | USV PHARMACEUTICAL CORPORATION (US) | 1987-05-26 | — | — | US | disclosed |
| US-4507300-A | Pyridotriazolopyrazine-diones for treating allergy | USV PHARMACEUTICAL CORPORATION (US) | 1985-03-26 | — | — | US | disclosed |
| EP-0039920-B1 | TRIAZALOQUINOXALIN-1,4-DIONES | USV PHARMACEUTICAL CORPORATION (US) | 1984-07-25 | — | — | EP | disclosed |
| US-4400382-A | Thiazoloquinoxalin-1,4-diones for treating allergy | USV PHARMACEUTICAL CORPORATION (US) | 1983-08-23 | — | — | US | disclosed |
| EP-0039920-A2 | Triazaloquinoxalin-1,4-diones | USV PHARMACEUTICAL CORPORATION (US) | 1981-11-18 | — | — | EP | disclosed |