Sugi Predict

Sugi Predict / Compounds / SCHEMBL1074409

SCHEMBL1074409

SCHEMBL1074409

CCOC(=O)c1cn(C2CCCCO2)nc1I

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.38
▸ CSNK1D P48730 1/20 0.38
▸ NPC1 O15118 2/20 0.36
▸ RAB9A P51151 2/20 0.36
▸ HPGD P15428 2/20 0.36
▸ TP53 P04637 1/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ CYP2C9 P11712 1/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ P2RY12 Q9H244 1/20 0.35
▸ ELANE P08246 2/20 0.35
▸ KDM4E B2RXH2 3/20 0.35
▸ NPSR1 Q6W5P4 3/20 0.35
▸ NR2F2 P24468 2/20 0.35
▸ MAPK1 P28482 2/20 0.35
▸ MAPT P10636 1/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ ABL1 P00519 1/20 0.35
▸ PDE4B Q07343 2/20 0.34
▸ MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29600809 1.00 LMNA (0.38) LMNACSNK1DNPC1RAB9AHPGD
SCHEMBL18946294 0.88 LMNA (0.40) LMNACSNK1DNPC1RAB9AHPGD
SCHEMBL21054420 0.87 LMNA (0.39) LMNACSNK1DNPC1RAB9AHPGD
SCHEMBL19374173 0.87 KDM4E (0.37) NPC1RAB9AHPGDTP53KDM4E
SCHEMBL21621425 0.85 LMNA (0.38) LMNACSNK1DNPC1RAB9AHPGD
SCHEMBL25465376 0.84 LMNA (0.39) LMNACSNK1DNPC1RAB9AHPGD
SCHEMBL14136588 0.84 CSNK1D (0.39) LMNACSNK1DNPC1RAB9AHPGD
SCHEMBL29222203 0.84 ELANE (0.39) LMNANPC1RAB9AHPGDTP53
SCHEMBL18209791 0.83 KDM4E (0.37) LMNACSNK1DNPC1RAB9AHPGD
SCHEMBL22235605 0.83 ELANE (0.39) LMNACSNK1DNPC1RAB9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240182426-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. 2024-06-06 — — US disclosed
US-11512053-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2022-11-29 — — US disclosed
CN-109265400-B Arginine methyltransferase inhibitors and uses thereof EPIZYME股份有限公司 2022-10-04 — — CN disclosed
EP-3212630-B1 NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS HOFFMANN LA ROCHE (CH) 2022-05-18 — — EP disclosed
US-11185531-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2021-11-30 — — US disclosed
US-11185531-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2021-11-30 — — US disclosed
US-20210078951-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. 2021-03-18 — — US disclosed
US-20210078951-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. 2021-03-18 — — US disclosed
US-10800743-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2020-10-13 — — US disclosed
US-10800743-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2020-10-13 — — US disclosed
WO-2014153214-A1 ARGININE METHYL TRANSFERASE INHIBTORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-25 — — WO disclosed
WO-2014153214-A1 ARGININE METHYL TRANSFERASE INHIBTORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-25 — — WO disclosed
WO-2014153172-A1 PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-25 — — WO disclosed
WO-2014144659-A1 PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-18 — — WO disclosed
WO-2014144659-A1 PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-18 — — WO disclosed
US-20110263610-A1 COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS IRM LLC (BM) 2011-10-27 — — US disclosed
US-20110263610-A1 COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS IRM LLC (BM) 2011-10-27 — — US disclosed
US-20110263610-A1 COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS IRM LLC (BM) 2011-10-27 — — US disclosed
EP-2274302-A2 COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS IRM LLC (BM) 2011-01-19 — — EP disclosed
WO-2009123948-A2 COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS IRM LLC (BM) 2009-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11512053-B2 Arginine methyltransferase inhibitors and uses thereof PRMT1, PRMT3, PRMT5 LMNA 3763/4885CSNK1D 1674/4885NPC1 631/4885
US-11185531-B2 Arginine methyltransferase inhibitors and uses thereof PRMT1, PRMT3, PRMT5 LMNA 3763/4885CSNK1D 1674/4885NPC1 631/4885
US-10800743-B2 Arginine methyltransferase inhibitors and uses thereof PRMT1, PRMT3, PRMT5 LMNA 3763/4885CSNK1D 1674/4885NPC1 631/4885
US-20210078951-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 LMNA 3763/4885CSNK1D 1674/4885NPC1 631/4885
US-20240182426-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 LMNA 3763/4885CSNK1D 1674/4885NPC1 631/4885
US-20110263610-A1 COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS IP6K1, IP6K2, IP6K3 LMNA 2895/4885CSNK1D 811/4885NPC1 880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.