Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | PMM2 | O15305 | 1/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYBB | P04839 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746433 | 0.87 | KMT2A (0.38) | IDO1TDO2IDO2ALDH1A1HTT | |
| SCHEMBL10749275 | 0.81 | METAP2 (0.54) | IDO1ALDH1A1HTTMETAP2KDM4E | |
| SCHEMBL10749509 | 0.81 | METAP2 (0.51) | IDO1ALDH1A1HTTMETAP2KDM4E | |
| SCHEMBL10954133 | 0.81 | METAP2 (0.46) | IDO1ALDH1A1HTTMETAP2KDM4E | |
| SCHEMBL10746865 | 0.81 | METAP2 (0.55) | IDO1ALDH1A1HTTMETAP2KDM4E | |
| SCHEMBL5916836 | 0.76 | METAP2 (0.49) | IDO1ALDH1A1HTTMETAP2KDM4E | |
| SCHEMBL5916565 | 0.76 | RAB9A (0.54) | ALDH1A1HTTMEN1CYP3A4MAPT | |
| SCHEMBL10501892 | 0.74 | METAP2 (0.66) | IDO1ALDH1A1HTTMETAP2KDM4E | |
| SCHEMBL10501872 | 0.74 | METAP2 (0.62) | IDO1ALDH1A1HTTMETAP2KDM4E | |
| SCHEMBL10502027 | 0.73 | METAP2 (0.62) | METAP2MPIPHOSPHO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| US-4550168-A | Benzisoselenazolones and a process for the treatment of inflammatory diseases | A. NATTERMANN & CIE GMBH (DE) | 1985-10-29 | — | — | US | disclosed |
| EP-0100899-A2 | Benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1984-02-22 | — | — | EP | disclosed |